Friday, October 18, 2019

Applied molecular biology Essay Example | Topics and Well Written Essays - 500 words

Applied molecular biology - Essay Example One of the subclasses was germinal-center B-cell-like DLBCL which showed an expression pattern the same as the mature germinal-center B-cells and portended a more favorable prognosis with a 60% five-year survival rate. Besides that, two other DLBCL subclasses, these are, type-3 DLBCL and activated B-cell-like DLBCL, presented much less favorable prognoses with a 35% five-year survival rate. From all these and the researches, it may be possible to determine the patients that might benefit from more aggressive therapies such as chemotherapy regimens or bone marrow transplants when DLBCL is diagnosed. HD DNA microarray studies have highlighted molecular pathways that are important in cancer subclasses. Example, researchers have observed that several genes in the activated B-cell subclass of DLBCL were downstream targets of the NFkB transcription factor. They proved that NFkB activity is higher in this DLBCL subtype thereby suggesting that drugs targeting the NFkB may be effective in the treatment of these tumors. (Cain, 2011) Gene expression profiling of tumor specimens may be useful in the pre-selection of patients who may benefit from drug treatment. It can also be used in examining gene expression profiles of cancers following chemotherapy so as to determine whether the tumors are responding to treatment. In this method, detailed patient-specific molecular information would be used to predict an effective therapy. (Schwab,

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